Comorbidity Between Obsesive-Compulsive Disorder and Bipolar Disorder: an Exploration of Clinical Features


Articol din publicatia Timisoara Medical Journal nr. 2/2005
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Ovidiu L. Bumbea
Department of Psychiatry, Alba County Hospital

Correspondence to:
Ovidiu Bumbea, Department of Psychiatry, Alba County Hospital, 1-3 Unirii Street, Alba Iulia
Tel: +40258811661
Email: obumbea@yahoo.co.uk

ABSTRACT

Objective: The present investigation deals with the clinical characteristics of the interface between obsessive-compulsive disorder (OCD) and bipolar disorder, (BD) as it appears in a setting of routine clinical practice.

M.D. Gheorghe*

Actualmente, sunt suficient de numeroase argumente, privind implicarea unor circuite neuroanatomice si a unor sisteme de neurotransmitatori (NT) in neurobiologia depresiei primare sau secundare. Astfel, sunt 2 circuite neuroanatomice, care sunt acreditate cu responsabilitati in fiziopatologia tulburarilor afective, si anume:
- circuitul cortico-talamo-limbic, care include amigdala, nucleul mediodorsal talamic si cortexul prefrontal;
- circuitul cortico-talamo-pallido-striato-limbic, care include in principal striatul si globus pallidus.

M.D. Gheorghe*, Corina Tudor, Anca Dragan, R. Ciurea, I. Isacu

Actualmente, este acceptata ideea ca 29-46% dintre pacientii depresivi sunt nonresponsivi la tratamentul antidepresiv, chiar si in situatiile unor doze adecvate si pe o perioada de timp suficienta (1)...